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. 2008 Sep 22;155(8):1224–1234. doi: 10.1038/bjp.2008.360

Figure 7.

Figure 7

Contractile responses to noradrenaline in mouse prostate. (a) Concentration–response curves for noradrenaline in WT and AKO mouse prostate. Mean±s.e.mean of 4–6 experiments. (b) Effects of silodosin, BMY 7378 and prazosin on the contractile response to noradrenaline in the AKO mouse prostate. This is a representative result obtained from three AKO mice. The response induced by 100 μM noradrenaline in the control was equivalent to 18.5 mg, which was taken as 100%. Prazosin (1 nM) produced insurmountable inhibition. (c) Contractile responses induced by 100 μM noradrenaline and 10 μM α,β-methylene ATP (α,β-Me ATP). Mean±s.e.mean of 3–6 experiments. *Significantly different from other columns (P<0.01). AKO, α1A-adrenoceptor gene knockout; WT, wild type.