Table 2.
Pharmacological characteristics of noradrenaline-induced contractions in WT mouse vas deferens and prostate
| Antagonist |
pKB |
|
|---|---|---|
| Vas deferens | Prostate | |
| Prazosin | 7.7±0.2 | 8.2±0.3 |
| Silodosin | 9.7±0.2a | 9.6±0.3a |
| RS-17053 | NI | 6.9±0.2a |
| 5-Methylurapidil | 7.6±0.2 | 7.4±0.3 |
| BMY 7378 | NI | NI |
Abbreviations: RS-17053, N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-α, α-dimethyl-1H-indole-3-ethamine hydrochloride; WT, wild type.
Mean±s.e.mean of 4–6 experiments.
NI indicates no inhibition at 0.1 μM BMY 7378 and 1 μM RS-17053.
pKB values were calculated by the Schild analysis.
a
Estimated at 1 nM silodosin or 1 μM RS-17053 by the concentration ratio method (Furchgott, 1972).