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. 2008 Oct 6;155(8):1185–1194. doi: 10.1038/bjp.2008.354

Figure 6.

Figure 6

Effects of combined administration of veratridine (125 nM), dofetilide (7.5 or 10 nM) and with or without HMR 1556 (100 nM) on the beat-to-beat variability of ventricular repolarization during pacing at cycle length (CL) of 500 ms. (a) The beat-to-beat variability was measured as the s.d. of 10 consecutive monophasic action potential (MAP) duration at 90% repolarization (MAPD90) during pacing CL of 500 ms. (b) A representative plot of individual MAPD90 values vs the beat number in a rabbit heart treated with veratridine+7.5 nM dofetilide+100 nM HMR 1556. Mean±s.d., n=6. *P<0.05 vs veratridine+7.5 nM dofetilide.