Table 1.

Number of spontaneous Torsades de Pointes episodes and R on T premature beats in perfused rabbit ventricles

	Torsades de Pointes episodes			R on T premature beats
	V+7.5D	V+7.5D+H	V+10D	V+7.5D	V+7.5D+H	V+10D
Mean±s.d.	4±6	22±18†	5±5	11±16	55±45‡	21±16
Median (range)	2 (0–16)	20 (0–45)	3 (0–12)	3 (0–37)	56 (1–119)	25 (0–45)
No. of heartsa	4 in 6	5 in 6	5 in 6	4 in 6	6 in 6	5 in 6

^aNumber of hearts with at least one episode of TdP or R on T premature beats.

V=125 nM veratridine; 7.5D=7.5 nM dofetilide; 10D=10 nM dofetilide; H=100 nM HMR 1556.

^†P<0.05 vs V+7.5D or V+10D; ^‡P<0.05 vs V+7.5D.