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. 2008 Sep 22;155(8):1235–1249. doi: 10.1038/bjp.2008.370

Figure 5.

Figure 5

Effect of gallotannin or 3-galloyl-1,2-O-isopropylidene glucose on cell death triggered by 24 h exposure to 1-methyl-3-nitro-1-nitrosoguanidine (MNNG). Cells were exposed to 100 μM gallotannin (1) or 100 μM 3-galloyl-1,2-O-isopropylidene glucose (4) in the presence or absence of 100 μM MNNG for 1 h and cell death was evaluated 24 h later by means of methylthiazolyl tetrazolium (MTT) reduction or lactate dehydrogenase (LDH) release assays. Both PARG inhibitors were present in the incubating media for 1 (a), 3 (b), 6 h (c) (see time lines on right of a–c). Bars are the mean±s.e.mean of three experiments conducted in duplicate. *P<0.05 vs control (ctrl), #P<0.05 vs MNNG (ANOVA+Tukey's post hoc test).