Table 2.
Effect of the NK1 receptor agonist septide (0.1 μM) and the NK2 receptor agonist β-A-NKA (0.1 μM) on the contractions induced by electrical field stimulation (EFS) in the mouse small intestine, obtained in the absence of NK1 and NK2 receptor antagonists RP67580 and nepadutant, respectively
| EFS | Control | Septide | Control | β-A-NKA |
|---|---|---|---|---|
| 0.5 Hz | 26.0±4.8 | 24.6±4.7 | 31.0±5.4 | 27.8±4.6 |
| 1 Hz | 36.1±5.0 | 32.3±5.5 | 39.4±4.9 | 35.8±4.4 |
| 2 Hz | 42.9±5.1 | 40.7±4.9 | 47.5±4.8 | 44.8±6.1 |
| 4 Hz | 50.0±7.9 | 53.8±8.0 | 52.2±5.1 | 48.9±8.5 |
Contractions are expressed as percentage of a 50-mM KCl contraction and shown as mean±s.e.mean. Student's t-test for paired observations did not show significant differences (n=6).