Table 2. Ratios (co-administration/alonea) of mean PK parameters for CP cycle 2/cycle 1 and for ASA404 cycle 2/cycle 7 (n=6).

	Total carboplatinb	Free carboplatinb	Paclitaxelc	Paclitaxel metabolitec	Total ASA404d	Free ASA404d
AUC(0−t)	1.19	1.38	1.10	0.96	1.05	7.95
95% CI	0.97, 1.41	0.98, 1.77	0.93, 1.27	0.62, 1.29	0.46, 1.64	2.05, 13.84
C max	1.26	1.36	0.88	1.04	1.01	5.72
95% CI	0.76, 1.76	0.37, 2.35	0.69, 1.07	0.69, 1.40	0.50, 1.52	2.01, 9.43

^aIn cycle 1 CP was given alone, in cycle 2 CP was co-administered with ASA404 and in cycle 7 ASA404 was given alone.

^bt=20.25 h for carboplatin.

^ct=45 h for paclitaxel.

^dt=43.75 h for ASA404.