Table 4. Most common grade 3 and 4 toxicities (safety population).

	No. of patients (%)
	ASA404-CP (n=37)		CP (n=36)
Toxicity	Grade 3	Grade 4	Grade 3	Grade 4
Neutropenia	8 (21.6)	15 (40.5)	10 (27.8)	4 (11.1)
Leukopenia	5 (13.5)	5 (13.5)	9 (25.0)	1 (2.8)
Alopecia	7 (18.9)	1 (2.7)	10 (27.8)	0
Hyperglycaemia	5 (13.5)	0	9 (25.0)	0
Neuropathy	2 (5.4)	0	7 (19.4)	0
Anaemia	3 (8.1)	0	5 (13.9)	0
Thrombocytopenia	2 (5.4)	2 (5.4)	2 (5.6)	0
Gastrointestinal disorders	3 (8.1)	0	2 (5.6)	1 (2.8)
Infection	4 (10.8)	0	1 (2.8)	0
Arthralgia, back or extremity pain	2 (5.4)	0	3 (8.3)	0
Cardiac disorders	3 (8.1)	1 (2.7)	1 (2.8)	0
Hypokalaemia	3 (8.1)	0	0	0
Respiratory, thoracic and mediastinal	3 (8.1)	0	0	0
Infusion site burning/pain	2 (5.4)	0	0	0
Dehydration	1 (2.7)	0	1 (2.8)	0
Anaphylactic shock or hypersensitivity	0	0	2 (5.6)	0
Neoplasms benign, malignant and unspecified	0	0	2 (5.6)	0
Flushing or hypotension	0	0	2 (5.6)	0
Febrile neutropenia	0	1 (2.7)	1 (2.8)	0

ASA404-CP=ASA404 combined with carboplatin and paclitaxel; CP=carboplatin and paclitaxel.