Table 2. Relationship between CRC risk and the sixty-three common mtDNA variants.
|
MAF
|
Adjusted resultsa
|
Unadjusted results
|
||||
|---|---|---|---|---|---|---|
| SNP | Case | Control | P-value | OR (95% CI) | P-value | OR (95% CI) |
| G752A | 0.018 | 0.018 | 0.99 | 1.00 (0.68, 1.47) | 0.95 | 0.99 (0.67, 1.46) |
| G1440A | 0.033 | 0.027 | 0.18 | 1.24 (0.91, 1.68) | 0.19 | 1.23 (0.90, 1.67) |
| G1721A | 0.058 | 0.054 | 0.54 | 1.07 (0.86, 1.35) | 0.52 | 1.08 (0.86, 1.35) |
| T2160C | 0.014 | 0.012 | 0.61 | 1.13 (0.71, 1.78) | 0.60 | 1.13 (0.72, 1.79) |
| G2708A | 0.434 | 0.438 | 0.75 | 0.98 (0.88, 1.09) | 0.80 | 0.99 (0.89, 1.10) |
| G3012A | 0.256 | 0.247 | 0.41 | 1.05 (0.93, 1.19) | 0.41 | 1.05 (0.93, 1.19) |
| T3198C | 0.102 | 0.089 | 0.10 | 1.16 (0.97, 1.39) | 0.12 | 1.15 (0.96, 1.38) |
| A3481G | 0.080 | 0.094 | 0.09 | 0.85 (1.02, 0.71) | 0.07 | 0.85 (0.70, 1.02) |
| A3721G | 0.011 | 0.012 | 0.55 | 0.86 (1.40, 0.53) | 0.59 | 0.87 (0.54, 1.42) |
| G3916A | 0.026 | 0.026 | 0.88 | 0.98 (0.70, 1.36) | 0.94 | 0.99 (0.71, 1.37) |
| C3993T | 0.025 | 0.023 | 0.65 | 1.08 (1.53, 0.77) | 0.72 | 1.07 (0.76, 1.50) |
| A4025G | 0.019 | 0.020 | 0.75 | 0.94 (1.37, 0.64) | 0.65 | 0.92 (0.63, 1.34) |
| T4217C | 0.213 | 0.203 | 0.32 | 1.07 (0.94, 1.22) | 0.39 | 1.06 (0.93, 1.20) |
| T4337C | 0.025 | 0.025 | 0.99 | 1.00 (0.72, 1.40) | 0.99 | 1.00 (0.72, 1.40) |
| T4562C | 0.012 | 0.012 | 0.99 | 1.00 (0.62, 1.61) | 0.96 | 0.99 (0.61, 1.59) |
| G4581A | 0.037 | 0.039 | 0.64 | 0.94 (0.71, 1.23) | 0.72 | 0.95 (0.72, 1.25) |
| G4770A | 0.030 | 0.025 | 0.20 | 1.23 (0.90, 1.69) | 0.22 | 1.22 (0.89, 1.67) |
| A4918G | 0.100 | 0.105 | 0.58 | 0.95 (1.13, 0.80) | 0.51 | 0.94 (0.79, 1.12) |
| T5005C | 0.020 | 0.023 | 0.60 | 0.91 (0.63, 1.30) | 0.54 | 0.89 (0.62, 1.28) |
| A5391G | 0.011 | 0.011 | 0.80 | 0.94 (1.54, 0.57) | 0.87 | 0.96 (0.58, 1.57) |
| G5461A | 0.055 | 0.047 | 0.21 | 1.16 (0.92, 1.48) | 0.19 | 1.17 (0.92, 1.48) |
| T5496C | 0.014 | 0.015 | 0.67 | 0.91 (0.59, 1.41) | 0.62 | 0.90 (0.58, 1.39) |
| A5657G | 0.016 | 0.010 | 0.06 | 1.58 (2.56, 0.98) | 0.06 | 1.57 (0.97, 2.52) |
| C6046T | 0.011 | 0.011 | 0.80 | 0.94 (1.54, 0.57) | 0.86 | 0.96 (0.58, 1.57) |
| T6153C | 0.012 | 0.012 | 0.90 | 0.97 (0.60, 1.58) | 0.97 | 0.99 (0.61, 1.61) |
| T6222C | 0.016 | 0.013 | 0.27 | 1.28 (0.82, 1.98) | 0.29 | 1.27 (0.82, 1.97) |
| G6261A | 0.018 | 0.019 | 0.83 | 0.96 (0.65, 1.41) | 0.80 | 0.95 (0.65, 1.40) |
| C6372T | 0.015 | 0.011 | 0.22 | 1.34 (2.12, 0.84) | 0.22 | 1.33 (0.84, 2.11) |
| G6735A | 0.012 | 0.010 | 0.45 | 1.22 (0.73, 2.01) | 0.47 | 1.20 (0.73, 1.99) |
| A7769G | 0.046 | 0.038 | 0.11 | 1.24 (1.61, 0.95) | 0.13 | 1.22 (0.94, 1.58) |
| G8270A | 0.034 | 0.032 | 0.61 | 1.08 (0.81, 1.45) | 0.66 | 1.07 (0.80, 1.43) |
| G8698A | 0.098 | 0.103 | 0.61 | 0.96 (0.80, 1.14) | 0.53 | 0.95 (0.80, 1.12) |
| A9668G | 0.014 | 0.012 | 0.48 | 1.18 (1.86, 0.75) | 0.52 | 1.16 (0.74, 1.83) |
| T9699C | 0.084 | 0.096 | 0.12 | 0.86 (0.72, 1.04) | 0.10 | 0.86 (0.72, 1.03) |
| T9900C | 0.014 | 0.017 | 0.41 | 0.84 (0.55, 1.28) | 0.42 | 0.84 (0.55, 1.28) |
| T10035C | 0.037 | 0.033 | 0.37 | 1.14 (0.86, 1.51) | 0.32 | 1.15 (0.87, 1.53) |
| A10045G | 0.011 | 0.011 | 0.79 | 1.07 (1.78, 0.65) | 0.94 | 1.02 (0.62, 1.69) |
| T10239C | 0.036 | 0.035 | 0.99 | 1.00 (0.76, 1.33) | 0.90 | 1.02 (0.77, 1.35) |
| G10399A | 0.213 | 0.211 | 0.87 | 1.01 (1.15, 0.89) | 0.85 | 1.01 (0.89, 1.15) |
| T10464C | 0.105 | 0.109 | 0.69 | 0.97 (0.82, 1.14) | 0.59 | 0.95 (0.81, 1.13) |
| A10551G | 0.079 | 0.093 | 0.08 | 0.85 (1.02, 0.70) | 0.07 | 0.84 (0.70, 1.01) |
| G10590A | 0.014 | 0.015 | 0.62 | 0.90 (0.58, 1.39) | 0.62 | 0.90 (0.58, 1.38) |
| T10916C | 0.012 | 0.011 | 0.82 | 1.06 (0.65, 1.72) | 0.84 | 1.05 (0.65, 1.71) |
| G11378A | 0.020 | 0.020 | 0.87 | 0.97 (0.67, 1.41) | 0.88 | 0.97 (0.67, 1.41) |
| A11468G | 0.222 | 0.228 | 0.66 | 0.97 (1.10, 0.86) | 0.59 | 0.97 (0.85, 1.09) |
| T11486C | 0.021 | 0.019 | 0.61 | 1.10 (0.76, 1.60) | 0.61 | 1.10 (0.76, 1.60) |
| A11813G | 0.082 | 0.084 | 0.90 | 0.99 (1.19, 0.82) | 0.79 | 0.97 (0.81, 1.18) |
| G11915A | 0.018 | 0.021 | 0.56 | 0.89 (0.61, 1.31) | 0.52 | 0.88 (0.61, 1.29) |
| A12309G | 0.223 | 0.229 | 0.70 | 0.98 (1.11, 0.86) | 0.64 | 0.97 (0.86, 1.10) |
| G12373A | 0.224 | 0.229 | 0.69 | 0.97 (0.86, 1.10) | 0.62 | 0.97 (0.86, 1.10) |
| T12415C | 0.019 | 0.020 | 0.72 | 0.93 (0.64, 1.36) | 0.80 | 0.95 (0.66, 1.39) |
| T12706C | 0.074 | 0.072 | 0.91 | 0.99 (0.81, 1.21) | 0.81 | 1.02 (0.84, 1.25) |
| A13781G | 0.035 | 0.034 | 0.93 | 1.01 (1.35, 0.76) | 0.83 | 1.03 (0.77, 1.37) |
| A14234G | 0.082 | 0.085 | 0.83 | 0.98 (1.18, 0.81) | 0.72 | 0.97 (0.80, 1.17) |
| T14471C | 0.019 | 0.013 | 0.09 | 1.43 (0.94, 2.17) | 0.08 | 1.44 (0.95, 2.18) |
| T14767C | 0.492 | 0.498 | 0.57 | 0.97 (0.87, 1.08) | 0.64 | 0.98 (0.88, 1.08) |
| T14799C | 0.162 | 0.164 | 0.94 | 0.99 (0.86, 1.15) | 0.85 | 0.99 (0.86, 1.14) |
| G15044A | 0.042 | 0.045 | 0.57 | 0.93 (0.72, 1.20) | 0.63 | 0.94 (0.73, 1.21) |
| A15219G | 0.041 | 0.041 | 0.99 | 1.00 (1.30, 0.77) | 0.98 | 1.00 (0.77, 1.30) |
| C15834T | 0.021 | 0.021 | 0.99 | 1.00 (1.44, 0.70) | 0.98 | 1.01 (0.70, 1.45) |
| C15905T | 0.037 | 0.039 | 0.57 | 0.92 (1.22, 0.70) | 0.66 | 0.94 (0.72, 1.24) |
| A15925G | 0.061 | 0.062 | 0.80 | 0.97 (1.21, 0.78) | 0.90 | 0.99 (0.79, 1.23) |
| G15929A | 0.100 | 0.104 | 0.64 | 0.96 (0.81, 1.14) | 0.56 | 0.95 (0.80, 1.13) |
CI=confidence interval; MAF=minor allele frequency; OR=odds ratio.
a
Adjusted for age and gender.