Table 2. Mutation rate and 95% confidence limits estimated from binary marker data.

Mutation marker	n	Mutation rate estimated from n patients (95% confidence interval)	Total sample size	Overall death rate	Upper bound of effect size	Lower and upper bounds for mutation rate	Stopping
PI3 kinase	131	0.15 (0.09, 0.21)	1000	0.6	1.5	(0.067, 0.933)	No
K-ras	223	0.48 (0.41, 0.55)	1000	0.6	1.5	(0.067, 0.933)	No
B-raf	204	0.30 (0.24, 0.37)	1000	0.6	1.5	(0.067, 0.933)	No
TGFβR-II	393	0.038 (0.019, 0.057)	1000	0.6	1.5	(0.067, 0.933)	Yes
MSI	446	0.24 (0.20, 0.28)	1000	0.6	1.5	(0.067, 0.933)	No

MSI=microsatellite instability.