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Augmentation therapy modulates downstream effecters of Akt to apoptosis. The downstream effects of the Akt pathway were examined by Western blotting. Bad was phosphorylated by cisplatin (5 μmol/L) treatment, while LY294002 (10 μmol/L) inhibited the phosphorylation. Augmentation with LY294002 weakened Bad phosphorylation and increased the cleavage of caspases-3.
