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Diagram showing the primary circuits and neurotransmitters implicated in drug-induced reinstatement. VTA, ventral tegmental area, cell body regions of mesocorticolimbic DA pathway; NAc, nucleus accumbens; mPFC, medial prefrontal cortex; VP/SNr, ventral pallidum/substantia nigra reticulata; PPT/LDT, peduncular pontine and laterodorsal tegmental nuclei. Grey, dopamine; black, glutamate.
