Table 3.
Effect of intracranial injections of pharmacological agents on context-induced reinstatement of drug seeking. (BLA, basolateral amygdala; CPu, caudate putamen; DH, dorsal hippocampus; PFC, prefrontal cortex; VTA, ventral tegmental area.)
| cocaine | heroin | anatomical specificity | |
|---|---|---|---|
| VTA: LY379268 | Bossert et al. (2004) | no effect in substantia nigra | |
| accumbens shell: LY379268, SCH 23390 | Bossert et al. (2006, 2007) | no effect in accumbens core (SCH 23390) and CPu (LY379268) | |
| DH: tetrodotoxin | Fuchs et al. (2005) | no effect in trunk of somatosensory cortex | |
| BLA: tetrodotoxin | Fuchs et al. (2005) | no effect in barrel field of somatosensory cortex | |
| dorsal medial PFC: tetrodotoxin | Fuchs et al. (2005) | no effect in ventral medial PFC | |
| dorsolateral CPu: muscimol+baclofen | Fuchs et al. (2006) | no effect in somatosensory cortex | |
| BLA–DH disconnection: muscimol +baclofen | Fuchs et al. (2007) | note: contralateral but not ipsilateral injections were effective | |
| BLA-dorsal medial PFC disconnection: muscimol+baclofen | Fuchs et al. (2007) | note: both contralateral and ipsilateral injections were effective |