Table 4.

Summary of Fos immediate early gene neuroanatomical mapping studies on context-induced reinstatement of drug seeking. (Under ‘cocaine’ or ‘alcohol’, we list brain sites where there are significant differences in Fos expression between groups of rats exposed to the training context (ABA) versus the distinct (ABB) or recent (AAA) extinction context. Under ‘anatomical specificity’, we provide a partial list of brain sites where group differences in Fos expression were not observed. BLA, basolateral amygdala; BNST, bed nucleus of stria terminalis; CPu, caudate putamen; PFC, prefrontal cortex; VTA, ventral tegmental area.)

	cocaine	alcohol	anatomical specificity
Marinelli et al. (2007); c-fos mRNA		BLA	accumbens core and shell
		lateral amygdala	CPu
		hippocampus CA3 area	septum
		(non-significant trend in CA1 and CA2)	BNSTVTAcentral amygdala
Hamlin et al. (2007); Fos protein		BLA	accumbens core and rostral pole
		lateral hypothalamus	accumbens dorsomedial shell
		ventral accumbens shell	dorsomedial and perifornical hypothalamus
			ventral and dorsal medial PFC
			VTA
			substantia nigra
Hamlin et al. (2008); Fos protein	BLA		Dorsal medial PFC
	lateral hypothalamus		accumbens core and shell
	ventral medial PFC		CPu
			central amygdala
			lateral amygdala
			BNST
			dorsomedial and perifornical hypothalamus
			VTA
			substantia nigra