Table 2.

The structure, cytotoxicity and lipid typology of phosphoramide analogues.

phosphoramide general structure
compound number	R1	R2	R3	R4	EC50/μMa	lipid typologyb
14	C6H13	H	CH3	CH3	1000	undetermined
15	C12H25	H	CH3	CH3	230	type I
16	C16H33	H	CH3	CH3	110	type I
17	C18H37	H	CH3	CH3	140	type I
18	oleyl	H	CH3	CH3	130	type I
19	C18H37	H	CH3	C2H5	40	type I
20	C6H13	C6H13	CH3	CH3	140	undetermined
21	C3H7	C15H31	CH3	CH3	23	type I
22	C6H13	C12H25	CH3	CH3	77	undetermined
23	C12H25	H	H	CH3	250	type I

cyclic phosphoramide general structure
compound number	R1	R2	R3	EC50/μMa	lipid typologyb
24	C16H33	H	CH3	750	type 0
25	C6H13	H	H	700	undetermined
26	C12H25	H	H	20	type 0
27	C16H33	H	H	60	type 0

^aA standard error of ±10% should be applied when interpreting these data.

^bLipid typologies were determined by polarizing optical microscopy; those in italics were deduced because the typology of structurally similar compounds is known; some typologies were undetermined because the solubility of the compounds in aqueous solution was too low.