Table 1. Azole susceptibilities and CgPDR1 mutations from C. glabrata clinical isolates.
| Strain | Site of isolation | CgPDR1 mutationb | MIC (µg ml−1)a | ||
| FLCc | ITCc | KTCc | |||
| DSY486 | Oropharynx | - | 16 | 1 | 1 |
| DSY489 | Oropharynx | L328F (G984T) | 128 | 2 | 2 |
| DSY738 | Oropharynx | - | 8 | 0.5 | 1 |
| DSY739 | Oropharynx | R376W (C1126T) | 64 | 2 | 2 |
| DSY2253 | Oropharynx | - | 16 | 1 | 1 |
| DSY2254 | Oropharynx | D1082G (A3245G) | 128 | 2 | 2 |
| DSY2235 | Oropharynx | - | 4 | 0.125 | 0.125 |
| DSY2234 | Oropharynx | T588A (A1762G) | 32 | 1 | 1 |
| DSY701 | Oropharynx | 4 | 0.25 | 0.25 | |
| DSY704 | Oropharynx | T607S (C1820G) | 32 | 1 | 1 |
| DSY529 | Oropharynx | - | 4 | 0.5 | 0.5 |
| DSY530 | Oropharynx | E1083Q (G3247C) | 64 | 2 | 2 |
| DSY753 | Oropharynx | - | 4 | 0.125 | 0.125 |
| DSY754 | Oropharynx | Y584C (A1751G) | 32 | 1 | 1 |
| DSY726 | Oropharynx | - | 8 | 0.25 | 0.25 |
| DSY727 | Oropharynx | D876Y (G2626T) | 64 | 2 | 2 |
| DSY562 | Oropharynx | - | 8 | 0.125 | 0.125 |
| DSY565 | Oropharynx | I280F (G840C) | 128 | 2 | 2 |
| DSY2256 | Oropharynx | - | 4 | 2 | 1 |
| DSY2257 | Oropharynx | N691D (A2071G) | 32 | 1 | 1 |
| DSY759 | Oropharynx | - | 4 | 0.5 | 0.125 |
| DSY2268 | Oropharynx | S316I (G947T) | 32 | 1 | 1 |
| DSY2270 | Oropharynx | - | 8 | 1 | 1 |
| DSY2271 | Oropharynx | D261G (A782G) | 128 | 2 | 2 |
| DSY2272 | Oropharynx | - | 4 | 0.5 | 0.5 |
| DSY2273 | Oropharynx | R293I (G878T) | 32 | 2 | 1 |
| DSY2276 | Oropharynx | - | 8 | 0.5 | 0.5 |
| DSY2277 | Oropharynx | R592S (G1776C) | 32 | 2 | 1 |
| DSY2278 | Oropharynx | - | 4 | 0.5 | 0.5 |
| DSY2279 | Oropharynx | G583S (G1747A) | 32 | 0.5 | 0.5 |
| DSY2281 | Oropharynx | - | 8 | 0.25 | 0.25 |
| DSY2282 | Oropharynx | - | 64 | 2 | 1 |
| DSY755 | Oropharynx | - | 4 | 0.25 | 0.125 |
| DSY756 | Oropharynx | S343F (C1028T) | 128 | 2 | 2 |
| DSY2316 | Oropharynx | - | 8 | 1 | 1 |
| DSY2315 | Oropharynx | R376G (C1126G) | 32 | 1 | 1 |
| DSY773 | Oropharynx | - | 16 | 0.5 | 1 |
| DSY774 | Oropharynx | R376G (C1126G) | 32 | 1 | 1 |
| DSY2317 | Oropharynx | - | 4 | 0.25 | 0.5 |
| DSY717 | Oropharynx | - | 64 | 2 | 2 |
| DSY2324 | Oropharynx | - | 4 | 0.25 | 0.125 |
| DSY2325 | Oropharynx | - | 128 | 2 | 2 |
a
MICs to these antifungal agents were determined by broth microdilution method in accordance with the CLSI M27-A2 document (National Committee for Clinical Laboratory Standards, 2002).
b
Numbers correspond to the positions of amino acid changes while numbers in parentheses correspond to the position of changed nucleotides changed in CgPDR1 relative to the ATG start codon.
c
FLC: Fluconazole; ITC: itraconazole; KTC: ketoconazole.