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. 2009 Jan 7;4(1):e4146. doi: 10.1371/journal.pone.0004146

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Genes that were significantly up-regulated (red) or down-regulated (green) were clustered into a Venn diagram. There were 9 significantly up-regulated and 4 significantly down-regulated genes in the testes collected from 20% CR male rats compared to the genes from testes collected from control (ad libitum) male rats. Ovaries collected from 20% CR female rats showed 33 significantly up-regulated (red) and 10 significantly down-regulated (green) genes compared to control (ad libitum) female rats. There were no common gene alterations between the 20% CR male and female gonadal tissues. Names of the significantly altered genes can be found in Table S1.