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. 2009 Jan 7;4(1):e4146. doi: 10.1371/journal.pone.0004146

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Genes that were significantly up-regulated (red) or down-regulated (green) were clustered into a Venn diagram. There were 47 significantly up-regulated and 12 significantly down-regulated genes in the testes collected from 40% CR male rats compared to controls. Ovaries collected from 40% CR female rats showed 24 significantly up-regulated (red) and 32 significantly down-regulated (green) genes compared to the control ad libitum females. There was 1 common gene altered in the gonads of both the male and female rats in this dietary group. This gene, chordc1, was up regulated in female gonadal tissue and down regulated in male gonadal tissue. Names of the significantly altered genes can be found in Table S1.