Table 1. Allele distribution and frequency of IL2RA SNPs in patients with multiple sclerosis and healthy controls.
| SNP | Alleles, n (%) | OR minor allele [95% CI] | P-value | ||||
| Cases | Controls | This worka | GWAS/MSb | T1Dc | |||
| rs1570538d | C | 734 (47.8) | 851 (51.6) | 0.86 [0.75–0.99] | 0.033/0.04d | ||
| SNP1 | T | 802 (52.2) | 799 (48.4) | ||||
| rs2104286 | T | 1237 (82.3) | 1426 (79.1) | 0.81 [0.68–0.96] | 0.017 | 2.16×10−7 | |
| SNP2 | C | 265 (17.7) | 378 (20.9) | ||||
| rs12722489 | G | 1216 (88.6) | 1186(87.2) | 0.87 [0.69–1.10] | 0.278 | 2.96×10−8 | 0.52 |
| SNP3 | A | 156 (11.4) | 1742(12.7) | ||||
| rs10795791 | A | 933 (64.4) | 1094 (60.6) | 0.85 [0.74–0.98] | 0.027 | 1.4×10−6 | |
| SNP4 | G | 515 (35.6) | 710 (39.4) | ||||
| rs4147359 | G | 1105 (72.6) | 1228 (69.0) | 0.84 [0.72–0.98] | 0.023 | 1.7×10−5 | |
| SNP5 | A | 417 (27.4) | 552 (31.0) | ||||
| rs7090530e | A | 741 (48.9) | 996 (54.2) | 1.23 [1.07–1.41] | 0.003 | 3.6×10−10 | |
| SNP6 | C | 767 (51.0) | 840 (45.8) | ||||
| rs41295061f | C | 1436 (94.5) | 1605 (93.2) | 0.80 [0.60–1.07] | 0.135 | 2.8×10−12 | |
| SNP7 | A | 84 (5.5) | 117 (6.8) | ||||
| rs35285258e , g | C | 921 (62.4) | 1193 (67.7) | 1.26 [1.09–1.46] | 0.0016 | 5.3×10−4 | |
| SNP8 | T | 555 (37.6) | 569 (32.3) | ||||
a
P-values = Pearson's goodness-of-fit chi-square (df = 1).
b
GWAS/MS combined analysis including 1540 family trios, 2322 case subjects, and 5418 control subjects.8
c
T1D study from 2965 cases and 2548 controls [13].
d
Data from our previous work [10]. IL2RA/MS association study from 346 cases and 413 controls included in the present study.
e
rs7090530 and rs35285258 survived Bonferroni correction.
f
rs41295061 named ss52580101 in T1D study [13].
g
rs35285258 named ss52580135 in T1D study [13].