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. 1997 Mar;89(3):191–196.

Serum lipid and lipoprotein levels in Ghanaians with diabetes mellitus and hypertension.

A Nyarko 1, K Adubofour 1, F Ofei 1, J Kpodonu 1, S Owusu 1
PMCID: PMC2608237  PMID: 9094844

Abstract

Both diabetes mellitus and hypertension alter lipid and lipoprotein metabolism and increase the risk of coronary artery disease. We have reported previously on lipid and lipoprotein levels in healthy Ghanaians, and this study deals with the levels of these biochemical parameters in Ghanaians with diabetes mellitus and hypertension. Fasting serum lipoproteins were determined on blood samples drawn from healthy male and female Ghanaians as well as age-matched individuals with either diabetes or hypertension. Cholesterol, high-density lipoprotein cholesterol (HDL-C), triglycerides, and fasting blood glucose were measured. Low-density lipoprotein cholesterol (LDL-C) and very low-density lipoprotein cholesterol (VLDL-C) were derived. Total serum cholesterol levels were 4.43 +/- 0.22 mmol/L and 4.67 +/- 0.26 mmol/L for diabetic males and females, respectively. High-density lipoprotein was 1.55 +/- 0.09 mmol/L and 1.50 +/- 0.09 mmol/L for male and female diabetics, respectively. Lipid and lipoprotein levels in the hypertensive patients did not differ from the above values. The levels of cholesterol and lipoprotein obtained in Ghanaians with hypertension and diabetes mellitus were similar to those of their age-matched healthy controls. These results suggest a reduced risk of coronary artery disease from the atherogenic effects of cholesterol in Ghanaians with diabetes mellitus and hypertension.

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Selected References

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  1. Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
  2. Ash K. O., Hentschel W. M. High-density lipoproteins estimated by an enzymatic cholesterol procedure, with a centrifugal analyzer. Clin Chem. 1978 Dec;24(12):2180–2184. [PubMed] [Google Scholar]
  3. Assmann G., Schulte H. The Prospective Cardiovascular Münster (PROCAM) study: prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. Am Heart J. 1988 Dec;116(6 Pt 2):1713–1724. doi: 10.1016/0002-8703(88)90220-7. [DOI] [PubMed] [Google Scholar]
  4. Bertrand E. Coronary heart disease in black Africans: an overview. East Afr Med J. 1995 Jan;72(1):37–41. [PubMed] [Google Scholar]
  5. Facchini F., Chen Y. D., Clinkingbeard C., Jeppesen J., Reaven G. M. Insulin resistance, hyperinsulinemia, and dyslipidemia in nonobese individuals with a family history of hypertension. Am J Hypertens. 1992 Oct;5(10):694–699. doi: 10.1093/ajh/5.10.694. [DOI] [PubMed] [Google Scholar]
  6. Giles W. H., Pacqué M., Greene B. M., Taylor H. R., Muñoz B., Cutler M., Douglas J. Prevalence of hypertension in rural west Africa. Am J Med Sci. 1994 Nov;308(5):271–275. doi: 10.1097/00000441-199411000-00003. [DOI] [PubMed] [Google Scholar]
  7. King H., Rewers M. Diabetes in adults is now a Third World problem. World Health Organization Ad Hoc Diabetes Reporting Group. Ethn Dis. 1993;3 (Suppl):S67–S74. [PubMed] [Google Scholar]
  8. Kitange H. M., Swai A. B., Masuki G., Kilima P. M., Alberti K. G., McLarty D. G. Coronary heart disease risk factors in sub-Saharan Africa: studies in Tanzanian adolescents. J Epidemiol Community Health. 1993 Aug;47(4):303–307. doi: 10.1136/jech.47.4.303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Lithell H., Pollare T., Vessby B. Metabolic effects of pindolol and propranolol in a double-blind cross-over study in hypertensive patients. Blood Press. 1992 Aug;1(2):92–101. doi: 10.3109/08037059209077499. [DOI] [PubMed] [Google Scholar]
  10. MacMahon S. W., Macdonald G. J., Blacket R. B. Plasma lipoprotein levels in treated and untreated hypertensive men and women. The National Heart Foundation of Australia Risk Factor Prevalence Study. Arteriosclerosis. 1985 Jul-Aug;5(4):391–396. doi: 10.1161/01.atv.5.4.391. [DOI] [PubMed] [Google Scholar]
  11. Muna W. F. Cardiovascular disorders in Africa. World Health Stat Q. 1993;46(2):125–133. [PubMed] [Google Scholar]
  12. Nyarko N. K., Adubofour K. O., Ofei F., Pobee J. O., Owusu S. K. Serum lipids and lipoprotein in adult Ghanaians. J Intern Med. 1994 Sep;236(3):251–253. doi: 10.1111/j.1365-2796.1994.tb00792.x. [DOI] [PubMed] [Google Scholar]
  13. Onitiri A. C., Sander M., Boyo A. E. Serum lipids and lipoproteins in healthy Africans. Clin Chim Acta. 1977 Nov 15;81(1):57–61. doi: 10.1016/0009-8981(77)90413-2. [DOI] [PubMed] [Google Scholar]
  14. Oyelola O. O., Ajayi A. A., Babalola R. O., Stein E. A. Plasma lipids, lipoproteins, and apolipoproteins in Nigerian diabetes mellitus, essential hypertension, and hypertensive-diabetic patients. J Natl Med Assoc. 1995 Feb;87(2):113–118. [PMC free article] [PubMed] [Google Scholar]
  15. Ragoobirsingh D., Davidson J. B. The effect of demographic factors on serum lipids in diabetics of Trinidad and Tobago. Possible association with ischaemic heart disease. West Indian Med J. 1989 Jun;38(2):99–104. [PubMed] [Google Scholar]
  16. Reaven G. M., Hoffman B. B. Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am J Med. 1989 Dec 8;87(6A):2S–6S. doi: 10.1016/0002-9343(89)90488-9. [DOI] [PubMed] [Google Scholar]
  17. Reaven G. M., Lithell H., Landsberg L. Hypertension and associated metabolic abnormalities--the role of insulin resistance and the sympathoadrenal system. N Engl J Med. 1996 Feb 8;334(6):374–381. doi: 10.1056/NEJM199602083340607. [DOI] [PubMed] [Google Scholar]
  18. Seedat Y. K., Mayet F. G., Latiff G. H., Joubert G. Study of risk factors leading to coronary heart disease in urban Zulus. J Hum Hypertens. 1993 Dec;7(6):529–532. [PubMed] [Google Scholar]
  19. Semenkovich C. F., Ostlund R. E., Jr, Schechtman K. B. Plasma lipids in patients with type I diabetes mellitus. Influence of race, gender, and plasma glucose control: lipids do not correlate with glucose control in black women. Arch Intern Med. 1989 Jan;149(1):51–56. [PubMed] [Google Scholar]
  20. Sosenko J. M., Breslow J., Miettinen O. S., Gabbay K. H. Hyperglycemia and plasma lipid levels: covariations in insulin-dependent diabetes. Diabetes Care. 1982 Jan-Feb;5(1):40–43. doi: 10.2337/diacare.5.1.40. [DOI] [PubMed] [Google Scholar]
  21. Sparling P. B., Noakes T. D., Steyn K., Jordaan E., Jooste P. L., Bourne L. T., Badenhorst C. Level of physical activity and CHD risk factors in black South African men. Med Sci Sports Exerc. 1994 Jul;26(7):896–902. [PubMed] [Google Scholar]
  22. Venter C. P., Joubert P. H. Ethnic differences in response to beta 1-adrenoceptor blockade by propranolol. J Cardiovasc Pharmacol. 1984 Mar-Apr;6(2):361–364. doi: 10.1097/00005344-198403000-00024. [DOI] [PubMed] [Google Scholar]
  23. Vorster H. H., Silvis N., Venter C. S., van Ryssen J. J., Huisman H., van Eeden T. S., Walker A. R. Serum cholesterol, lipoproteins, and plasma coagulation factors in South Africa blacks on a high-egg but low-fat intake. Am J Clin Nutr. 1987 Jul;46(1):52–57. doi: 10.1093/ajcn/46.1.52. [DOI] [PubMed] [Google Scholar]
  24. Walden C. E., Knopp R. H., Wahl P. W., Beach K. W., Strandness E., Jr Sex differences in the effect of diabetes mellitus on lipoprotein triglyceride and cholesterol concentrations. N Engl J Med. 1984 Oct 11;311(15):953–959. doi: 10.1056/NEJM198410113111505. [DOI] [PubMed] [Google Scholar]
  25. Zhou H. H., Koshakji R. P., Silberstein D. J., Wilkinson G. R., Wood A. J. Altered sensitivity to and clearance of propranolol in men of Chinese descent as compared with American whites. N Engl J Med. 1989 Mar 2;320(9):565–570. doi: 10.1056/NEJM198903023200905. [DOI] [PubMed] [Google Scholar]

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