Table 2.
Twenty-four Membered Library Prepared by Nucleophilic Opening of Naphthyridine and Pyridoazepine Epoxides (Scheme 5).a
| Reagents |
 1c |
 1d |
 1h |
 1i |
 |
Et2NH |
|---|---|---|---|---|---|---|
10c |
12a (75%/100%) |
12b (66%/85%) |
12c(73%/89%) |
12d (68%/65%) |
12e (92%/100%) |
12f(91%/97%) |
10h |
12g (74%/100%) |
12h (79%/89%) |
12i (81%/98%) |
12j (78%/73%) |
12k (94%/92%) |
12l (92%/97%) |
10i |
12m (68%/100%) |
12n (72%/100%) |
12o (73%/100%) |
12p (80%/80%) |
12q (90%/100%) |
12r (96%/100%) |
11c |
13a (74%/100%) |
13b (70%/100%) |
13c(80%/83%) |
13d(72%/74%) |
13e (93%/95%) |
13f (95%/100%) |
a
(% yield/% purity as determined by ELSD-MS).