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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cancer Prev Res (Phila). 2008 Oct 1;1(5):362–368. doi: 10.1158/1940-6207.CAPR-08-0101

Fig. 5.

Fig. 5

Qu degradation increases caspase-3 and PARP cleavage. HaCaT cells were treated with 50 μmol/L Qu in the presence and absence of 1 mmol/L AA for 1 h before UVB irradiation and for 16 h after 250 J/m2 UVB. Cleavage of caspase-3 (A) and PARP (B) were induced by both UVB irradiation and Qu treatment alone. UVB irradiation followed by Qu treatment resulted in an increase in caspase-3 cleavage compared with either UVB or Qu alone. AA had no effect alone on caspase-3 or PARP cleavage; however, stabilization of Qu with AA resulted in a significant reduction in the cleavage of both proteins compared with Qu alone. Representative of three independent experiments.