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. Author manuscript; available in PMC: 2008 Dec 24.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2006 May;47(5):2114–2124. doi: 10.1167/iovs.05-1068

FIGURE 2.

FIGURE 2

The mKATP agonist, diazoxide, mimicked the neuroprotective effects of IPC in a dose-dependent manner. Diazoxide was injected IP 24 hours before 45 minutes of ischemia and compared with injection of DMSO vehicle (leftmost bar). See Figure 1 for a description of the method. The significant IPC-mimicking by diazoxide (P < 0.004) 40 mg/kg was inhibited by 5-HD (200 mg/kg, P < 0.0003 vs. diazoxide). n = 10 rats in the diazoxide 40-mg/kg group, and five to seven rats in the others.