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C3H/HeJ (TLR4 mutation) and C3H/HeOuJ (TLR4 intact) mice were pretreated with PGN prior to challenge with live S. aureus. The mice were observed for mortality for 7 days after the challenge. Mice that were pretreated had significantly better survival after the S. aureus challenge than control mice. (p < 0.05, N = 10-11 per group)
