Table 2. Single-SNP association of homocysteine genes with PXFS, PXFG and PXFNG.

Gene	SNP	Minor allele	Minor allele frequency				p value*
			PXFS	PXFG	PXFNG	Controls	PXFS	PXFG	PXFNG
MTHFR	rs1801131	C	0.348	0.368	0.295	0.370	0.79	1.00	0.45
MTHFR	rs1801133	T	0.363	0.369	0.348	0.360	1.00	1.00	1.00
MTHFR	rs17037396	T	0.087	0.110	0.037	0.094	0.85	0.70	0.26
MTR	rs12096955	T	0.400	0.407	0.385	0.346	0.32	0.33	0.62
MTR	rs2229274	A	0.018	0.016	0.023	0.035	0.45	0.43	1.00
MTR	rs1805087	G	0.188	0.203	0.141	0.212	0.47	0.83	0.16
MTRR	rs326122	G	0.196	0.190	0.212	0.180	0.78	0.88	0.69
MTRR	rs1532268	T	0.315	0.328	0.283	0.435	0.053	0.10	0.10
MTRR	rs161870	A	0.477	0.468	0.500	0.488	0.89	0.88	1.00
MTRR	rs162036	A	0.161	0.175	0.130	0.143	0.66	0.52	1.00
MTHFD1	rs8006686	C	0.213	0.225	0.185	0.115	0.015	0.015	0.25
MTHFD1	rs2236225	T	0.453	0.434	0.489	0.479	0.56	0.33	0.62
MTHFD1	rs11627387	G	0.271	0.272	0.269	0.267	1.00	1.00	1.00
CBS	rs2124459	C	0.426	0.401	0.471	0.374	0.33	0.65	0.13
CBS	rs1801181	T	0.338	0.328	0.369	0.335	1.00	0.92	0.59
CBS	rs5742905	C	0.092	0.098	0.076	0.065	0.28	0.25	0.81
CBS	rs234715	G	0.210	0.218	0.176	0.225	0.80	1.00	0.65

The asterisk indicates that p values were obtained from Fisher’s exact test when compared to controls. The Bonferroni corrected significance level was 0.003 (0.05/17).