Table 4. Gene-based association of homocysteine genes with PXFS.
| Gene | SNPs |
p value |
|
|---|---|---|---|
| Haplotype test* | Set-based test# | ||
| MTHFR | rs1801131 , rs1801133, rs17037396 | 0.97 | 1.00 |
| MTR | rs12096955 , rs2229274, rs1805087 | 0.68 | 1.00 |
| MTRR | rs326122 , rs1532268, rs161870, rs162036 | 0.85 | 0.19 |
| MTHFD1 | rs8006686 , rs2236225, rs11627387 | 0.30 | 0.04 |
| CBS | rs2124459 , rs1801181, rs5742905, rs234715 | 0.23 | 1.00 |
The asterisk indicates that the p values were obtained from the omnibus haplotype test using PLINK (version 1.04) [30] and the the sharp (hash mark) indicates that the p values were obtained from the set-based test by a permutation of 10,000 times using PLINK (version 1.04) [30]. The Bonferroni corrected significance level was 0.01 (0.05/5).