Figure 3.

Axonal mechanical sensitivity is induced by nerve inflammation. The sciatic nerve is depicted in the middle of the image, with the shaded oval area indicating CFA-induced inflammation. The individual neurons lead to receptive fields in muscle or skin (right and top), and centrally to dorsal roots (left), for recording. When inflamed, the normally insensitive axons become mechanically sensitive. DRG = dorsal root ganglion. (From Bove GM et al 2003, used with permission.)