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. 2008 Dec 16;6(1):9–17. doi: 10.7150/ijms.6.9

Figure 6.

Figure 6

Active and total MMP-8 and MMP-9 levels in ALI with disease progression. 6A. Mean (± SEM) MMP-8 activity is shown for subjects who developed prolonged ALI (all subjects requiring ventilatory support ≥ 10 days, N=13). With ALI progression, using pooled samples from days ≥ 10, active MMP-8 level increased by approximately 2-fold. > 97% of total MMP-8 found was active in later samples compared to 47% in pooled samples < 10 days. 6B. Active and total MMP-9 levels decreased by approximately 21 and 6-fold respectively with ALI progression [* p < 0.004 for active and † p < 0.0002 for total MMP-9 activity in earlier ALI (days 0-10) compared with later ALI (≥ 10 days)]. In later stages of ALI, > 80% of total MMP-9 detected were present as pro-enzymes.