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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2008 Jul 9;49(12):5611–5618. doi: 10.1167/iovs.08-1698

Figure 6.

Figure 6

UbcM2, the mouse counterpart of UBE2E3, is downregulated during RPE maturation in the developing mouse eye. (A) Representative photomicrographs of X-Gal-labeled cryosections from E13 embryos (Aa, Ab) and P17 mice (Ac, Ad). (Ab, Ad) Wild-type samples; (Aa, Ac) samples from UbcM2 heterozygous mice. WT, wild type; UNP, undifferentiated retinal precursors; OS, outer segments; IS, inner segments; ONL, outer nuclear layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. (B) Graph of X-Gal spots counted per mm of RPE from an average of 10 sections from each of two animals for each time point. Error bars, SEM. *Statistically significant, according to a two-tailed distribution, two-sample, equal-variance Student's t-test with P < 0.0002.