Skip to main content
. Author manuscript; available in PMC: 2008 Dec 27.
Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):947–956. doi: 10.1002/ajmg.b.30366

Table II.

Transmethylation and transsulfuration metabolites in autistic cases and controls

Control* Autistic* p value
(n=73) (n=80)
Methionine (µmol/L) 28.0 ± 6.5 20.6 ± 5.2 <0.0001
SAM (nmol/L) 93.8 ± 18 84.3 ± 11 <0.0001
SAH (nmol/L) 18.8 ± 4.5 23.3 ± 7.9 <0.0001
SAM/SAH ratio 5.5 ± 2.8 4.0 ± 1.7 <0.0001
Adenosine (µmol/L) 0.19 ± 0.13 0.28 ± .13 0.001
Homocysteine (µmol/L) 6.0 ± 1.3 5.7 ± 1.2 0.03
Cystathionine (µmol/L) 0.19 ± 0.1 0.24 ± 0.1 <0.0001
Cysteine (µmol/L) 207 ± 22 165 ± 14 <0.0001
Cysteinylglycine (µmol/L) 39.4 ± 7.3 38.9 ± 11 0.78
Total GSH (µmol/L) 7.53 ± 1.7 5.1 ± 1.2 <0.0001
Free GSH (µmol/L 2.2 ± 0.9 1.4 ± 0.5 <0.0001
GSSG (µmol/L) 0.24 ± 0.1 0.40 ± 0.2 <0.0001
Total GSH/GSSG Ratio 28.2 ± 7.0 14.7 ± 6.2 <0.0001
Free GSH/GSSG Ratio 7.9 ± 3.5 4.9 ± 2.2 <0.0001
*

Means ± SD

Abbreviations: SAM: S-adenosylmethionine; SAH: S-adenosylhomocysteine; GSH: glutathione; GSSG: glutathione disulfide