Table III.
Allele frequencies, genotype distributions, odds ratios, and 95% confidence intervals (CI) in autistic cases and controls. Significant and borderline significant differences are in bold type.
| SNP | Genotype | Cases | Controls | |
|---|---|---|---|---|
| No. (%) | No. (%) | OR (95% CI) | ||
| RFC-1 | A | 290 (42) | 176 (49) | Reference |
| 80 A>G | G | 408 (58) | 182 (51) | 1.36 (1.04,1.7) |
| AA | 55 (16) | 51 (28) | Reference | |
| GA | 180 (52) | 74 (41) | 2.26 (1.37,3.7) | |
| GG | 114 (33) | 54 (26) | 1.96 (1.15,3.3) | |
| GA+GG | 294 (84) | 128 (63) | 2.13 (1.4, 3.4) | |
| COMT | A | 340 (47) | 215 (54%) | Reference |
| 472G>A | G | 376 (53) | 181 (46) | 1.31 (1.02,1.7) |
| AA | 86 (24) | 57 (29) | Reference | |
| AG | 168 (47) | 101 (51) | 1.10 (0.7, 1.7) | |
| GG | 105 (29) | 40 (20) | 1.74 (1.02, 2.9) | |
| TCN2 | C | 375 (52) | 231 (58) | Reference |
| 776 C>G | G | 346 (48) | 169 (42) | 1.25 (0.97, 1.6) |
| CC | 108 (30) | 63 (32) | Reference | |
| CG | 159 (44) | 105 (52) | 0.88 (0.58, 1.3) | |
| GG | 93 (26) | 32 (16) | 1.70 (1.02, 2.8) | |
| CC+CG | 268 (74) | 168 (84) | 0.55 (0.35, 0.8) | |
| GSTM1 | +/+ | 176 (49) | 115 (57) | Reference |
| NULL | 182 (51) | 86 (43) | 1.37 (0.98,1.96) | |
| MTHFR | C | 444 (62) | 276 (67) | Reference |
| 677C>T | T | 268 (38) | 134 (33) | 1.24 (0.96, 1.6) |
| CC | 134 (38) | 93 (45) | Reference | |
| CT | 176 (49) | 90 (44) | 1.36 (.92, 1.99) | |
| TT | 46 (13) | 22 (11) | 1.45 (.79, 2.71) | |
| CT+TT | 222 (62) | 112 (55) | 1.38 (.96, 1.98) | |
| MTRR | A | 348 (49) | 172 (43) | Reference |
| 676A>G | G | 368 (51) | 232 (57) | 0.78 (0.61, 1.02) |
| AA | 91 (25) | 37 (18) | Reference | |
| AG | 166 (46) | 98 (49) | 0.69 (0.42, 1.1) | |
| GG | 101 (28) | 67 (33) | 0.61 (0.36, 1.03) | |
| AG+GG | 267 (75) | 165 (82) | 0.66 (0.42, 1.03) |
Abbreviations: RFC: Reduced Folate Carrier; TCN2: Transcobalamin II; COMT: Catechol-O-methyltransferase; GST: Glutathione-S-transferase; MTHFR: Methylenetetrathydrofolate reductase: MTRR: methionine synthase reductase