. Author manuscript; available in PMC: 2008 Dec 27.

Published in final edited form as: Am J Med Genet B Neuropsychiatr Genet. 2006 Dec 5;141B(8):947–956. doi: 10.1002/ajmg.b.30366

Table IV.

Gene-gene interactions

SNP	Genotype	Cases	Controls
		No.	No.	OR (95% CI)
TCN2 776 C>G/COMT 472 G>A	CC/CC	22	22	Reference
	GG/GG	35	5	7.0 (2.32, 21.2)

**RFC-1 80 A>G/MTHFR677C>T**	AA/CC	22	28	Reference
	GA/CT	89	35	3.24 (1.55, 6.78)
	GA/TT	24	7	4.40 (1.45, 14.0)
	GG/CT	58	24	3.10 (1.39, 6.84)

RFC-1 80 A>G/GSTM1 Null	AA/++	23	29	Reference
	GA/Null	90	30	3.78 (1.80, 7.95)
	GG/Null	53	25	2.67 (1.22, 5.89)

MTHFR 677 CT/MTHFR 1298AC	CT/AC	85	39	1.78 (0.97, 3.26)

MTHFR 677CT/ 1298AC/RFC 80G	(CT/AC) / GA	42	26	1.33 (1.33, 15.81)
	(CT/AC) / GG	25	12	3.57 (0.97, 13.49)