Fig. 3.

Structure of the ligand-free CprK_C200S.

A. DNA domain interface. A stereo view of the DNA-binding domain interface with key residues represented in atom coloured sticks.

B. Overlay of the CprK_C200S ligand-free sensor domains (ribbon model coloured as in Fig. 1) with the corresponding CprK_C200S:OCPA structure (in grey ribbons). Coloured arrows indicate relative motion of individual structural elements upon ligand binding.

C. Stereoview of an overlay of the ligand binding sites and immediate environment for both CprK_C200S and CprK_C200S:OCPA structures. For clarity, labels in the left panel indicate the position of CprK_C200S residues below the grey horizontal line and for CprK_C200S:OCPA residues when above that line.