Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Jun 16;69(2):520–533. doi: 10.1111/j.1365-2958.2008.06305.x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 The Authors Journal compilation © 2008 Blackwell Publishing Ltd

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

PMC Copyright notice

Fig. 1 — Pathway of thymidylate synthesis and primary site of action of inhibitors. SHMT, serine hydroxymethyltransferase; DHFR, dihydrofolate reductase; TS, thymidylate synthase; O/129, 2,4-diamino-6,7-diispropylpteridine; PTR1, pteridine reductase 1; TK, thymidine kinase; H₂F, dihydrofolate; H₄F, tetrahydrofolate; CH₂-CH₄F, 5, 10-methylene-tetrahydrofolate; FdUMP, 5-fluorodeoxyuridylate; GCS, glycine cleavage system.