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. Author manuscript; available in PMC: 2009 Aug 1.

Published in final edited form as: Neuropharmacology. 2008 May 24;55(2):204–214. doi: 10.1016/j.neuropharm.2008.05.016

Table 1.

LRP binding and NMDAR inhibitory potency of apoE peptides.

Peptide	K_d (µM)^a	IC₅₀ (µM)^b
apoE[133–149]	0.057 ± 0.002	1.3 ± 0.1
apoE[143–150]	0.72 ± 0.21	3.3 ± 0.1
apoE[145–150]	15.0 ± 6.0	17.5 ± 0.6
apoE[133–149/K143,146E]	6.7 ± 1.7	>100

^a

Values were obtained from SPR-monitored binding of peptides to immobilized LRP.

^b

Concentration of peptide needed to achieve 50% inhibition of NMDA/glycine-evoked currents in NR1b/2A-transfected HEK293 cells.