Table 3.
Biomarker levels measured at 6 months and 18 months, by intervention arms, adjusted for baseline values, age, gender and BMI, mean (SE)
| Outcomes | Diet+Exercise | Diet | Exercise | Control | P-value* | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| 6-Month N=46 |
18-Month N=46 |
6-Month N=48 |
18-Month N=48 |
6-Month N=45 |
18-Month N=45 |
6-Month N=52 |
18-Month N=53 |
Grp | Time | |
| HA (ng/ml) | 42.28 (3.79) | 45.33 (3.63) | 46.95 (3.64) | 44.21 (3.44) | 45.68 (3.67) | 43.45 (3.54) | 40.46 (3.58) | 47.67 (3.35) | .99 | .50 |
| AgKS (ng/ml) | 310.22 (7.62) | 310.93 (7.32) | 312.61 (7.29) | 306.38 (6.90) | 322.79 (7.35) | 314.11 (7.09) | 308.67 (7.17) | 286.66 (6.71) | .07 | .02 |
| COMP (U/L) | 10.80 (0.49) | 11.81 (0.46) | 11.58 (0.47) | 12.21 (0.44) | 12.77 (0.46) | 12.84 (0.44) | 11.75 (0.45) | 11.72 (0.42) | .04 | .10 |
| TGFβ1 (ng/ml) | 38.89 (1.14) | 39.06 (1.07) | 36.40 (1.08) | 36.65 (1.01) | 37.63 (1.08) | 38.46 (1.04) | 40.93 (1.04) | 39.41 (0.98) | .02 | .87 |
HA = hyaluronan, AgKS = antigenic keratan sulfate, COMP = cartilage oligomeric protein, TGF-β1 = transforming growth factor-B1.
*
Interactions for Group and time not statistically significant.