Table 6.
Association between change in biomarker levels at 18-months and change in outcome measures 18-months. Beta coefficient (SE) and p-value
| HA-Chg | AgKs-Chg | COMP-Chg | TGF-Beta1-Chg | |
|---|---|---|---|---|
| Outcomes | ||||
| 1.WEIGHT-Chg | 0.05 (.04) P=.20 |
0.04 (.02) P=.03 |
0.68 (.29) P=.02 |
−0.02 (.15) P=.89 |
| 2.WOMCFUNC-Chg | 0.004 (.003) P=.12 |
−0.002 (.001) P=.15 |
−0.03 (.02) P=.13 |
0.01 (.01) P=.92 |
| 3.WOMCPAIN-Chg | 0.001 (.003) P=.64 |
−0.003 (.001) P=.04 |
−0.03 (.02) P=.15 |
0.02 (.01) P=.79 |
| 4.WOMCSTIF-Chg | 0.001 (.003) P=.69 |
−0.0003 (.001) P=.85 |
−0.03 (.02) P=.25 |
0.003 (.01) =.79 |
| 5.DISTANCE-Chg | 0.55 (1.24) P=.66 |
−0.03 (.60) P=.96 |
−0.076 (9.9) =.94 |
−5.5 (5.1) P=.28 |
| 6.STCLTIME-Chg | −0.01 (.03) P=.56 |
0.006 (.01) P=.60 |
−0.23 (.20) P=.26 |
−0.02 (.11) =.85 |
| 7.JSW_LA-Chg | −0.0001 (.002) p=.98 |
0.0001 (.001) P=.91 |
0.04 (.02) P=.05 |
.003 (.01) =.81 |
| 8.JSW_MED-Chg | −0.004 (.002) P=.08 |
0.001 (.001) P=.65 |
−0.02 (.02) P=.34 |
−0.004 (.01) P=.68 |
| 9.SCORE-Chg | 0.001 (.001) P=.70 |
−0.0003 (.001) =.60 |
−0.001 (.01) P=.92 |
−0.01 (.01) P=.12 |
HA = hyaluronan, AgKS = antigenic keratan sulfate, COMP = cartilage oligomeric protein, TGF- β1 = transforming growth factor- β1, JSW = joint space width. Values shown are Beta coefficients (SE) followed by p values.