. Author manuscript; available in PMC: 2009 Nov 1.

Published in final edited form as: Clin Liver Dis. 2008 Nov;12(4):939–xi. doi: 10.1016/j.cld.2008.07.011

Table 2.

Diseases and Therapies in which Fibrosis can be Reduced by Treating the Underlying Disorder

Disease	Therapy
Hepatitis B	Lamivudine, others
Hepatitis C	^* Interferon alpha
Autoimmune hepatitis	Corticosteroids
Bile duct obstruction	Surgical decompression
Hemochromatosis	Iron depletion
^¶ Alcoholic hepatitis	Corticosteroids
^¶ Primary biliary cirrhosis	Ursodeoxycholic acid, MTX
^§ Non-alcholic steatohepatitis	PPAR gamma ligands

or PEG-interferon alpha, with or without ribavirin

^¶

The effect is minimal if present

^§

Evidence is preliminary at this point

References are given in the text

Abbreviations: MTX = methotrexate; PPAR = peroxisomal proliferator activated receptor