Table 3.

The top 10 prioritized SNPs from the NicSNP GWAS and candidate gene study ranked by weighted P-value (P/w)

SNP	Chr	Pos (bp)	Gene	Tier	Function	Mouse Conserva (%)	P-value (P)	N. Weightb (w)	W. P-valuec (P/w)	Rank by P	Rank by P/w
rs16969968	15	76 669,980	CHRNA5	1	Nonsynonymous	86	6.4E−04	2.8E+02	2.3E−06	199	1
rs1051730	15	76 681 394	CHRNA3	1	Synonymous	91	9.9E−04	9.9E+01	1.0E−05	267	2
rs6474413	8	42 670 221	CHRNB3	1	Locus	–	9.4E−05	6.8E+00	1.4E−05	33	3
rs578776	15	76 675 455	CHRNA3	1	3′/5′ promoter	–	3.1E−04	2.1E+01	1.4E−05	123	4
rs4142041	10	68 310 957	CTNNA3	–	Intron	–	5.6E−06	3.8E−01	1.5E−05	2	5
rs999	6	32 261 864	PBX2	–	3′/5′ promoter	–	1.4E−05	6.8E−01	2.1E−05	3	6
rs12623467	2	51 078 593	NRXN1	–	Intron	–	1.5E−05	3.8E−01	3.9E−05	4	7
rs2836823	21	39 286 525	–	–	–	–	1.5E−06	3.8E−02	4.0E−05	1	8
rs12380218	9	79 125 480	VPS13A	–	Intron	–	2.1E−05	3.8E−01	5.5E−05	6	9
rs2673931	5	135 717 335	TRPC7	–	Intron	72	3.9E−05	6.9E−01	5.6E−05	8	10

^aHuman/Mouse evolutionary conserved region – the percentage of conservation.

^bNormalized Weight.

^cWeighted P-value.