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. Author manuscript; available in PMC: 2008 Dec 29.
Published in final edited form as: Genesis. 2008 Aug;46(8):396–400. doi: 10.1002/dvg.20415

Figure 1.

Figure 1

A) murine chromosome 14. B) linearized Ednrb-cKO targeting vector. C) Ednrb-cKO targeted chromosome 14. D) Ednrb-cKO targeted chromosome after Cre-excision of exon 3. Numbered boxes indicate the location of exons in the 8.8 kb targeting vector. Triangles represent loxP sites flanking the Neomycin cassette (neo). Dashed lines indicate regions of homology, X represents location of homologous recombination. P represents an introduced PstI site used in genotyping the 5′ probe, H represents an introduced HindIII restriction site used in genotyping using the 3′ probe. The shaded boxes on A indicate the location of the 5′ probe and 3′ probes, respectively.