FIGURE 2.

The putative active site of M. tuberculosis VapC-5. The main chain atoms are represented as a ribbon diagram and colored as follows: VapB-5 is shown in green, VapC-5 α-helices are shown in magenta, β-strands in cyan and loops in gray. Residues involved in the active site formation are shown as green sticks for VapB-5 and yellow for VapC-5. For both proteins, N and O atoms are blue and red, respectively. The four acidic catalytic residues are in bold font. Water molecules are shown as cyan balls. Potential hydrogen bonds are depicted as cyan-dashed lines. For the purpose of clarity, only selected water molecules and hydrogen bonds are shown.