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. 2009 Jan 2;284(1):292–300. doi: 10.1074/jbc.M807233200

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Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — Altered cardiac function and arrhythmia in viable adult Smad7^ΔMH2-/- mice. A, histological analysis showed a very thin wall in the right ventricle in adult Smad7^ΔMH2-/- mice (at 9 months old). RA, right atrium; LA, left atrium; RV, right ventricle; LV, left ventricle; and VS, ventricular septum. B, echocardiograph analysis of wild-type and viable Smad7^ΔMH2-/- mice (at 3 months old, n = 5). Representative two-dimensional and M-mode images are shown. Measurement of various parameters of cardiac functions is shown in the lower panel, and ^* stands for p < 0.01. C, ECG analysis of wild-type and viable Smad7^ΔMH2-/- mice (at 3 months old). Representative ECG images reveal arrhythmia (arrows) in Smad7 mutant mice.