FIGURE 8.

Arrestin3-specific residues on the non-receptor-binding side of the molecule. The residues that are specific for arrestin3 (absent in the other three mammalian subtypes) were identified based on sequence alignment in (1). The positions of residues that represent nonconservative and conservative substitutions (as compared with arrestin2) are highlighted in red and green, respectively. Because the structure of arrestin3 was not solved, high-resolution structure of arrestin2 (PDB ID 1G4M) (27) was used to generate this picture. Three views are shown: upper panel, receptor-binding side (view down the concave sides of both domains); middle panel, side view; and lower panel, non-receptor-binding “back” of the arrestin molecule where signaling molecules interacting with the arrestin-receptor complex bind.