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Proposed model for the trapping function of PTPROt-CS. The predicted interaction between the c-abl region of bcr/abl and PTPROt is depicted. Only the key domains of bcr/abl and downstream signaling elements relevant to this study are shown. ABD, actin binding domain; PP, proline-rich region; Y-K, tyrosine kinase domain harboring Tyr-1294; S/T-K, Ser/Thr kinase domain harboring Tyr-177; Y-P*, mutated tyrosine phosphatase domain.
