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. 2009 Jan 2;284(1):381–388. doi: 10.1074/jbc.M806538200

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Copyright © 2009, The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — LRP1 governs adipocyte differentiation. Cells were treated with the adipogenic mixture containing the PPARγ agonist rosiglitazone for 10 days to stimulate differentiation. A, quantitative RT-PCR analysis of LRP1 in 3T3 preadipocytes, B, plates of LRP1(+/+), LRP1(-/-) MEFs, and 3T3-L1 preadipocytes. The extent of cellular lipid accumulation was determined by Oil Red O staining. C, micrographs of LRP1(+/+) and LRP1(-/-) MEFs. c and d show two different morphologies of lipid droplets that accumulate in LRP1(-/-) MEFs. D, triglyceride (at day 10) and (E) cholesterol and cholesteryl-ester quantifications during differentiation of LRP1(+/+) and LRP1(-/-) MEFs. F, quantitative RT-PCR analysis of HMG CoA reductase in MEFs during differentiation. G, Western blot analysis of LDL receptor in MEFs at day 10. T0, day 0; T10, day 10 of treatment. Scale bar, 50 μm. Results are means ± S.D. ^*, p < 0.05.