Figure 5. NA depletion enhances METH-induced striatal DA loss.
Shown are striatal tissue DA levels 7 days following saline or METH administration (5 mg/kg ×1, 5 mg/kg ×2, and 5 mg/kg ×3, 2 h apart) in (a) mice pretreated with DSP-4, (b) mice pretreated with fusaric acid, and (c) DBH −/− mice. Results were obtained from 5 animals per group and are expressed as the mean ±SEM. Differences among groups were evaluated using ANOVA.
*p<0.05 compared with controls, §p<0.05 compared with METH.