Table 1.

Time course of changes in NA levels (ng/mg protein) within different brain areas following various dosing paradigms of fusaric acid.

	STRIATUM			FRONTAL CORTEX			HIPPOCAMPUS			CEREBELLUM
	1 h	4 h	8 h	1 h	4 h	8 h	1 h	4 h	8 h	1 h	4 h	8 h
Control	0.90± 0.20	0.89± 0.04	1.03± 0.20	3.87± 0.19	3.56± 0.10	3.98± 0.62	4.08± 0.27	3.97± 0.24	4.03± 0.30	3.66± 0.32	3.43± 0.21	3.81± 0.31
FA 20mg/kg×1	0.71± 0.01	0.80± 0.04	1.10± 0.30	3.40± 0.21	3.22± 0.31	3.85± 0.40	3.62± 0.31	3.50± 0.21	3.46± 0.29	3.21± 0.25	3.06± 0.22	3.49± 0.29
FA 20mg/kg×2	0.68± 0.10	0.50± 0.01*	0.58± 0.11*	2.10± 0.33*	1.80± 0.22*	1.84± 0.31*	2.13± 0.21*	1.75± 0.19*	1.91± 0.20*	2.08± 0.14*	1.96± 0.15*	2.20± 0.17*
FA 40mg/kg×1	0.11± 0.01 a	ND	0.60± 0.30*	1.56± 0.21*	1.06± 0.22*	1.45± 0.27*	0.64± 0.19§	0.53± 0.12§	0.78± 0.21§	1.80± 0.15§	1.02± 0.12§	2.07± 0.18§
FA 40mg/kg×2	ND	ND	ND	0.70± 0.10§	0.49± 0.20§	0.53± 0.15§	0.30± 0.09§	0.18± 0.07§	0.22± 0.18§	0.59± 0.11§	0.29± 0.08§	0.37± 0.10§

Noradrenaline levels were measured in male C57/B1 mice at various time intervals after administration of either saline or different dosing of the DBH inhibitor, fusaric acid (20 mg/kg ×1 and ×2 or 40 mg/kg ×1 or ×2, 2 h apart) to induce a loss of NA. Results were obtained from 5 mice per group and are expressed as mean ±SEM values, in ng/mg of protein.

Differences among groups were evaluated using ANOVA with Sheffè's post hoc analysis:

^*p<0.05 compared with controls.

^§p<0.05 compared with control and lower dosing of FA.