Table 3.
Additive model *
| Comparison | First-line therapy, OR (95% CI) | Salvage therapy, OR (95% CI) |
|---|---|---|
| KA/VE vs CVD | 0.63 (0.14 to 2.12) | 0.96 (0.42 to 1.91) |
| TEC vs CVD | 1.79 (0.60 to 6.42) | 0.77 (0.33 to 1.55) |
| TEE vs CVD | 1.57 (0.47 to 6.18) | 0.54 (0.26 to 0.86) |
| TEC vs KA/VE | 2.85 (0.90 to 13.14) | 0.80 (0.36 to 1.81) |
| TEE vs KA/VE | 2.49 (0.73 to 12.60) | 0.56 (0.30 to 0.94) |
| TEE vs TEC | 0.87 (0.24 to 3.27) | 0.70 (0.35 to 1.20) |
Odds ratio (OR) estimates for the six possible regimen comparisons for both the first-line and the salvage setting along with 95% bootstrap confidence intervals (CIs) are shown. The four candidate drug regimens are cyclophosphamide, vincristine, and dexamethasone (CVD); ketoconazole plus doxorubicin alternating with vinblastine plus estramustine (KA/VE); paclitaxel, estramustine, and carboplatin (TEC); and paclitaxel, estramustine, and etoposide (TEE). The data used in this analysis were obtained directly from Thall et al. (1).