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. Author manuscript; available in PMC: 2008 Dec 29.
Published in final edited form as: Clin Cancer Res. 2007 Nov 15;13(22 Pt 1):6549–6554. doi: 10.1158/1078-0432.CCR-07-1088

Fig. 2.

Fig. 2

Telomere and telomerase status in normal and malignant hematopoietic cells. LSCs are distinct from LT-HSCs and ST-HSCs. LT-HSCs have relatively long telomeres, but low telomerase activity, which cannot maintain telomere length, and thus LT-HSC telomeres shorten when the cells replicate. ST-HSCs have long telomeres and up-regulate telomerase, enabling them to actively amplify. LSCs have high telomerase activity but short telomeres that essentially require maintenance by telomerase, thereby providing a target for therapeutic intervention.