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Notch signaling pathway. Notch ligands such as Jagged 1/2 bind to the extracellular domain of Notch receptors. Cleavage of the Notch receptors by α-secretase and γ-secretase releases the Notch intracellular domain, which translocates into the nucleus, resulting in transcription activation. γ-Secretase has been validated as a therapeutic target (see Table 1).
